Title : [Regulation of insulin sensitivity by subcellular GLUT4 targeting].

Pub. Date : 2005 Oct

PMID : 16296343






3 Functional Relationships(s)
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1 By contrast, Ubc9 gene silencing with siRNA caused a marked decrease in the GLUT4 level, whereas overexpression of the catalytically inactive mutant of Ubc9 increased GLUT4 and insulin-stimulated glucose transport to the level comparable to that with wild-type Ubc9. Glucose ubiquitin conjugating enzyme E2 I Homo sapiens
2 By contrast, Ubc9 gene silencing with siRNA caused a marked decrease in the GLUT4 level, whereas overexpression of the catalytically inactive mutant of Ubc9 increased GLUT4 and insulin-stimulated glucose transport to the level comparable to that with wild-type Ubc9. Glucose ubiquitin conjugating enzyme E2 I Homo sapiens
3 Thus, Ubc9 plays an indispensable role in the expression and maintenance of the insulin-sensitive glucose transport system in adipocytes. Glucose ubiquitin conjugating enzyme E2 I Homo sapiens