Title : Bioscavengers for the protection of humans against organophosphate toxicity.

Pub. Date : 2005 Dec 15

PMID : 16293236






1 Functional Relationships(s)
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1 Current antidotes for organophosphorus compounds (OP) poisoning consist of a combination of pretreatment with carbamates (pyridostigmine bromide), to protect acetylcholinesterase (AChE) from irreversible inhibition by OP compounds, and post-exposure therapy with anti-cholinergic drugs (atropine sulfate) to counteract the effects of excess acetylcholine and oximes (e.g., 2-PAM chloride) to reactivate OP-inhibited AChE. Atropine acetylcholinesterase (Cartwright blood group) Homo sapiens