Title : Modeling evolution of hydrogen bonding and stabilization of transition states in the process of cocaine hydrolysis catalyzed by human butyrylcholinesterase.

Pub. Date : 2006 Jan 1

PMID : 16288482






1 Functional Relationships(s)
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1 The computational results consistently reveal a unique role of the oxyanion hole (consisting of G116, G117, and A199) in BChE-catalyzed hydrolysis of cocaine, compared to acetylcholinesterase (AChE)-catalyzed hydrolysis of acetylcholine. Cocaine acetylcholinesterase (Cartwright blood group) Homo sapiens