Title : Estradiol and its metabolites 4-hydroxyestradiol and 2-hydroxyestradiol induce mutations in human breast epithelial cells.

Pub. Date : 2006 Apr 15

PMID : 16287077






1 Functional Relationships(s)
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1 Cells treated with E2 or 4-OHE2 at doses of 0.007 nM and 70 nM and 2-OHE2 only at a higher dose (3.6 microM) exhibited a 5 bp deletion in p53 exon 4. Estradiol tumor protein p53 Homo sapiens