Title : Analogues of oxytocin antagonists bearing a ureido group in the amino acid side chain at position 4 or 5.

Pub. Date : 2006 May

PMID : 16285023






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In the uterotonic assay, the substitution with the ureido group at Gln(4) results in retention of high antagonistic potency, albeit somewhat lower than that of PA, e.g. [Orn(Car)(4), Pen(6)]-PA and [Dab(Car)(4), Pen(6)]-PA having pA(2) = 8.52 and pA(2) = 8.42 respectively. Glutamine proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens