Title : Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease.

Pub. Date : 2005 Nov 17

PMID : 16279781






2 Functional Relationships(s)
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1 More importantly, these dual AChE inhibitors inhibit the AChE-induced A beta peptide aggregation with IC50 values 1 order of magnitude lower than that of propidium, thus being the most potent derivatives with this activity reported up to date. Propidium acetylcholinesterase (Cartwright blood group) Homo sapiens
2 More importantly, these dual AChE inhibitors inhibit the AChE-induced A beta peptide aggregation with IC50 values 1 order of magnitude lower than that of propidium, thus being the most potent derivatives with this activity reported up to date. Propidium acetylcholinesterase (Cartwright blood group) Homo sapiens