Title : Genetic influence of an ACTH receptor promoter polymorphism on adrenal androgen secretion.

Pub. Date : 2005 Nov

PMID : 16260430






4 Functional Relationships(s)
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1 Here we investigate the influence of an ACTH receptor promoter polymorphism affecting ACTH receptor gene transcription on ACTH-dependent dehydroepiandrosterone (DHEA) secretion. Dehydroepiandrosterone proopiomelanocortin Homo sapiens
2 Here we investigate the influence of an ACTH receptor promoter polymorphism affecting ACTH receptor gene transcription on ACTH-dependent dehydroepiandrosterone (DHEA) secretion. Dehydroepiandrosterone proopiomelanocortin Homo sapiens
3 RESULTS: In the 6-h ACTH stimulation test, CTC/CTC carriers showed a significantly higher DHEA response than CCC/CCC carriers (area under the curve: 19 367 +/- 2919 vs 11 098 +/- 1241 nmol/l per min; P < 0.04, Mann-Whitney U-test). Dehydroepiandrosterone proopiomelanocortin Homo sapiens
4 Thus, we might have identified one of the genetic factors responsible for variation in ACTH-dependent DHEA secretion. Dehydroepiandrosterone proopiomelanocortin Homo sapiens