Title : Induction of invasive mouse skin carcinomas in transgenic mice with mutations in both H-ras and p53.

Pub. Date : 2005 Oct

PMID : 16254190






1 Functional Relationships(s)
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1 Topical application to wild-type mice with benzo(a)pyrene (BaP) alone produced approximately 26% skin tumor incidence, whereas BaP treatment of p53(wt/wt)Hras(TG.AC/wt), p53(Val135/wt)Hras(wt/wt), and p53(Val135/wt)Hras(TG.AC/wt) mice produced a 75%, 77%, and 100% incidence of skin tumors, respectively. Benzo(a)pyrene transformation related protein 53, pseudogene Mus musculus