Pub. Date : 2006 Mar
PMID : 16249254
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Glutamine dose-dependently increased GAD-mediated formation of GABA, whereas glucose metabolism shunts part of this GABA to mitochondrial catabolism, involving alpha-KG-induced activation of GABA-T. | Glucose | 4-aminobutyrate aminotransferase | Homo sapiens |
| 2 | In absence of extracellular glutamine, glucose also contributed to GABA formation through aminotransferase generation of glutamate from alpha-KG; this stimulatory effect increased GABA release only when GABA-T activity was suppressed. | Glucose | 4-aminobutyrate aminotransferase | Homo sapiens |
| 3 | Glucose inhibits glutamine-driven GABA formation and release through increasing GABA-T shunt activity by its cellular metabolism. | Glucose | 4-aminobutyrate aminotransferase | Homo sapiens |