Pub. Date : 2005 Nov 1
PMID : 16239170
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In our present study, we investigated the effect of arsenite on Akt1 and eNOS and its involvement in cytotoxicity of vascular endothelial cells. | arsenite | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Our study demonstrated that arsenite decreased the protein levels of both Akt1 and eNOS accompanied with increased levels of ubiquitination of total cell lysates. | arsenite | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | We found that inhibition of the ubiquitin-proteasome pathway by MG-132 could partially protect Akt1 and eNOS from degradation by arsenite together with a proportional protection from the arsenite-induced cytoxicity. | arsenite | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Our study indicated that endothelial eNOS activity could be attenuated by arsenite via the ubiquitin-proteasome-mediated degradation of Akt1/eNOS as well as via direct inhibition of eNOS activity. | arsenite | AKT serine/threonine kinase 1 | Homo sapiens |