Pub. Date : 2005 Nov
PMID : 16225757
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | METHODS: Mouse models of ischemic ARF were treated with the specific ICE inhibitor AC-YVAD-CMK. | ac-yvad | chemokine (C-X-C motif) ligand 9 | Mus musculus |
| 2 | A renal function assay and renal morphological studies were employed to estimate the renal protective effect of AC-YVAD-CMK. | ac-yvad | chemokine (C-X-C motif) ligand 9 | Mus musculus |
| 3 | AC-YVAD-CMK therapy alleviated the clinical features of ARF, and increased the survival rate (P<0.01). | ac-yvad | chemokine (C-X-C motif) ligand 9 | Mus musculus |
| 4 | Furthermore, AC-YVAD-CMK therapy also decreased ICE activity, mature IL-18 protein expression, and IFN-gamma mRNA expression in renal tissue (P<0.05). | ac-yvad | chemokine (C-X-C motif) ligand 9 | Mus musculus |
| 5 | CONCLUSION: The selective ICE inhibitor AC-YVAD-CMK can effectively protect the kidney from acute ischemic lesions. | ac-yvad | chemokine (C-X-C motif) ligand 9 | Mus musculus |