Title : Inhibitory effects of caffeic acid phenethyl ester on cancer cell metastasis mediated by the down-regulation of matrix metalloproteinase expression in human HT1080 fibrosarcoma cells.

Pub. Date : 2006 May

PMID : 16214327






4 Functional Relationships(s)
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1 On this line, we examined the influence of CAPE on the gene expression of MMPs (MMP-2, MMP-9, MT1-MMP), tissue inhibitor of metalloproteinase-2 (TIMP-2) and in vitro invasiveness of human fibrosarcoma cells. caffeic acid phenethyl ester matrix metallopeptidase 2 Homo sapiens
2 Dose-dependent decreases in MMP and TIMP-2 mRNA levels were observed in CAPE-treated HT1080 human fibrosarcoma cells as detected by reverse transcriptase-polymerase chain reaction (RT-PCR). caffeic acid phenethyl ester matrix metallopeptidase 2 Homo sapiens
3 Gelatin zymography analysis also exhibited a significant down-regulation of MMP-2 and MMP-9 expression in HT1080 cells treated with CAPE compared to controls. caffeic acid phenethyl ester matrix metallopeptidase 2 Homo sapiens
4 In addition, CAPE inhibited the activated MMP-2 activity as well as invasion, motility, cell migration and colony formation of tumor cells. caffeic acid phenethyl ester matrix metallopeptidase 2 Homo sapiens