Title : Mutual augmentation of the induction of the histamine-forming enzyme, histidine decarboxylase, between alendronate and immuno-stimulants (IL-1, TNF, and LPS), and its prevention by clodronate.

Pub. Date : 2006 May 15

PMID : 16203021






1 Functional Relationships(s)
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1 We reported previously that in mice, (i) the inflammatory actions of N-BPs depend on IL-1, (ii) N-BP pretreatment augments both LPS-stimulated IL-1 production and HDC induction, and (iii) the co-administration of clodronate (a non-N-BP) with an N-BP inhibits the latter"s inflammatory actions (including HDC induction). n-bps interleukin 1 complex Mus musculus