Pub. Date : 2005 Oct
PMID : 16192772
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of Kv4.3/KChIP2.2 channels by bupivacaine and its modulation by the pore mutation Kv4.3V401I. | Bupivacaine | potassium voltage-gated channel subfamily D member 3 | Homo sapiens |
| 2 | This study elucidates the molecular mechanisms of bupivacaine interaction with complexes formed by Kv4.3 and KChIP2.2 as well as the modulatory effect of KChIP2.2. | Bupivacaine | potassium voltage-gated channel subfamily D member 3 | Homo sapiens |
| 3 | RESULTS: Inhibition of Kv4.3wt/KChIP2.2 channels by bupivacaine was concentration-dependent and reversible. | Bupivacaine | potassium voltage-gated channel subfamily D member 3 | Homo sapiens |
| 4 | KChIP2.2 altered the response of Kv4.3wt channels to bupivacaine and bupivacaine modulated KChIP2.2 effects on Kv4.3wt channels. | Bupivacaine | potassium voltage-gated channel subfamily D member 3 | Homo sapiens |
| 5 | CONCLUSIONS: These results indicate that bupivacaine blocks Kv4.3/KChIP2.2 channels from the open state. | Bupivacaine | potassium voltage-gated channel subfamily D member 3 | Homo sapiens |