Title : Fyn kinase-mediated phosphorylation of NMDA receptor NR2B subunit at Tyr1472 is essential for maintenance of neuropathic pain.

Pub. Date : 2005 Sep

PMID : 16190898






1 Functional Relationships(s)
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1 The present study demonstrates that Tyr1472 phosphorylation of NR2B subunits by Fyn kinase may have dual roles in the retention of NMDA receptors in the postsynaptic density and in activation of nitric oxide synthase, and suggests that PGE2 is involved in the maintenance of neuropathic pain via the EP1 subtype. Dinoprostone prostaglandin E receptor 1 (subtype EP1) Mus musculus