Title : The endothelium-dependent effects of thimerosal on mouse pial arterioles in vivo: evidence for control of microvascular events by EDRF as well as prostaglandins.

Pub. Date : 1992 Jul

PMID : 1618948






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Thimerosal causes synthesis and/or release of both endothelium-derived relaxing factor (EDRF) and prostaglandins from conductance vessels in vitro. Thimerosal alpha hemoglobin stabilizing protein Mus musculus
2 Thimerosal causes synthesis and/or release of both endothelium-derived relaxing factor (EDRF) and prostaglandins from conductance vessels in vitro. Thimerosal alpha hemoglobin stabilizing protein Mus musculus
3 The ability of thimerosal to dilate arterioles was eliminated not only by treatments thought to eliminate synthesis/release of EDRF, but also by cyclooxygenase inhibitors. Thimerosal alpha hemoglobin stabilizing protein Mus musculus
4 We conclude that the dilating effects of thimerosal on diameter require two endothelium-derived agents: EDRF and one or more prostaglandins acting in concert. Thimerosal alpha hemoglobin stabilizing protein Mus musculus
5 However, the inhibiting effect of thimerosal on local platelet adhesion/aggregation appears to be caused only by an increase in EDRF at the injured site. Thimerosal alpha hemoglobin stabilizing protein Mus musculus