Pub. Date : 2006 Mar
PMID : 16180010
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Involvement of the extracellular signal-regulated protein kinase pathway in phosphorylation of p53 protein and exerting cytotoxicity in human neuroblastoma cells (SH-SY5Y) exposed to acrylamide. | Acrylamide | tumor protein p53 | Homo sapiens |
| 2 | Using human neuroblastoma SH-SY5Y cells, effects of acrylamide on p53 protein and intracellular signal transducting pathways were examined. | Acrylamide | tumor protein p53 | Homo sapiens |
| 3 | Acrylamide increased p53, phosphorylated p53, and p53-associated protein murine double minute 2 (MDM2). | Acrylamide | tumor protein p53 | Homo sapiens |
| 4 | Hence, acrylamide increases p53 protein and its phosphorylation at Ser15 through ERK and/or PIKK pathways. | Acrylamide | tumor protein p53 | Homo sapiens |