Title : Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IkappaB kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia.

Pub. Date : 2005 Oct 3

PMID : 16171798






4 Functional Relationships(s)
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1 Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IkappaB kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia. Quercetin nitric oxide synthase 2, inducible Mus musculus
2 Quercetin could suppress LPS- and IFN-gamma-induced NO production and inducible nitric oxide synthase (iNOS) gene transcription, while quercetin-3"-sulfate had no effect. Quercetin nitric oxide synthase 2, inducible Mus musculus
3 Quercetin could suppress LPS- and IFN-gamma-induced NO production and inducible nitric oxide synthase (iNOS) gene transcription, while quercetin-3"-sulfate had no effect. Quercetin nitric oxide synthase 2, inducible Mus musculus
4 Quercetin-mediated inhibition of NO production and iNOS protein expression were partially reversed by heme oxygenase-1 antisense oligodeoxynucleotide, but was mimicked by hemin, a heme oxygenase-1 inducer. Quercetin nitric oxide synthase 2, inducible Mus musculus