Pub. Date : 2005 Sep
PMID : 16170023
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Resistance to TRAIL is associated with defects in ceramide signaling that can be overcome by exogenous C6-ceramide without requiring down-regulation of cellular FLICE inhibitory protein. | Ceramides | TNF superfamily member 10 | Homo sapiens |
| 2 | Mass spectrometry was used to compare ceramide content in untreated and TRAIL-treated cells. | Ceramides | TNF superfamily member 10 | Homo sapiens |
| 3 | Overall levels of ceramide were comparable in the cell lines but TRAIL-sensitive SW480 cells contained a higher percentage of C(16)-, and C(18)-ceramide and lower C(24)-ceramides than TRAIL-resistant SW620 cells. | Ceramides | TNF superfamily member 10 | Homo sapiens |
| 4 | Overall levels of ceramide were comparable in the cell lines but TRAIL-sensitive SW480 cells contained a higher percentage of C(16)-, and C(18)-ceramide and lower C(24)-ceramides than TRAIL-resistant SW620 cells. | Ceramides | TNF superfamily member 10 | Homo sapiens |
| 5 | Overall levels of ceramide were comparable in the cell lines but TRAIL-sensitive SW480 cells contained a higher percentage of C(16)-, and C(18)-ceramide and lower C(24)-ceramides than TRAIL-resistant SW620 cells. | Ceramides | TNF superfamily member 10 | Homo sapiens |
| 6 | Upon TRAIL treatment, ceramide (primarily C(16)-ceramide) increased in SW480 but not SW620 cells. | Ceramides | TNF superfamily member 10 | Homo sapiens |
| 7 | Exposure to TRAIL prior to ceramide was required to induce apoptosis, suggesting that ceramide plays a role in enhancing or amplifying TRAIL-mediated signaling. | Ceramides | TNF superfamily member 10 | Homo sapiens |
| 8 | Exposure to TRAIL prior to ceramide was required to induce apoptosis, suggesting that ceramide plays a role in enhancing or amplifying TRAIL-mediated signaling. | Ceramides | TNF superfamily member 10 | Homo sapiens |
| 9 | Our results suggest that ceramide plays a role in promoting TRAIL-mediated apoptosis and that TRAIL-resistant cancers may benefit from combination therapy with ceramide or agents that enhance ceramide accumulation. | Ceramides | TNF superfamily member 10 | Homo sapiens |
| 10 | Our results suggest that ceramide plays a role in promoting TRAIL-mediated apoptosis and that TRAIL-resistant cancers may benefit from combination therapy with ceramide or agents that enhance ceramide accumulation. | Ceramides | TNF superfamily member 10 | Homo sapiens |
| 11 | Our results suggest that ceramide plays a role in promoting TRAIL-mediated apoptosis and that TRAIL-resistant cancers may benefit from combination therapy with ceramide or agents that enhance ceramide accumulation. | Ceramides | TNF superfamily member 10 | Homo sapiens |