Pub. Date : 2005 Dec
PMID : 16160139
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A key serine for the GTPase-activating protein function of regulator of G protein signaling proteins is not a general target for 14-3-3 interactions. | Serine | paired like homeodomain 2 | Homo sapiens |
| 2 | We confirm that the interaction of RGS3 with 14-3-3tau and 14-3-3zeta requires Ser264 and not the RGS domain and show both that mutation of the conserved RGS domain serine, Ser496 in RGS3, to either alanine or aspartate does not prevent binding of 14-3-3 proteins and that 14-3-3 proteins do not inhibit GTPase-activating protein (GAP) activity against receptor-activated Galpha(o1). | Serine | paired like homeodomain 2 | Homo sapiens |
| 3 | We mutated the equivalent serine residue in the family B/R4 RGS proteins RGS1 and RGS16. | Serine | paired like homeodomain 2 | Homo sapiens |