Title : Neo-nicotinoid metabolic activation and inactivation established with coupled nicotinic receptor-CYP3A4 and -aldehyde oxidase systems.

Pub. Date : 2006 Feb 20

PMID : 16153789






1 Functional Relationships(s)
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1 For metabolism, the neo-nicotinoid is incubated with CYP3A4 and NADPH or AOX with the cosubstrate N-methyl-nicotinamide, terminating the reaction with ketoconazole or menadione, respectively, to inhibit further conversion. N-methylnicotinamide Aldox89A Drosophila melanogaster