Title : A randomized, placebo-controlled trial of certolizumab pegol (CDP870) for treatment of Crohn's disease.

Pub. Date : 2005 Sep

PMID : 16143120






2 Functional Relationships(s)
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1 Patients with baseline C-reactive protein levels of 10 mg/L or greater (n = 119) showed clearer separation between active treatment and placebo (week 12 clinical response: certolizumab 400 mg, 53.1%; placebo, 17.9%; P = .005; post hoc analysis) owing to a lower placebo response rate than patients with C-reactive protein levels of less than 10 mg/L. Certolizumab Pegol C-reactive protein Homo sapiens
2 High placebo response rates in the large patient subgroup with low C-reactive protein levels may have obscured statistical separation between certolizumab and placebo. Certolizumab Pegol C-reactive protein Homo sapiens