Title : Malignant transformation of human colon epithelial cells by benzo[c]phenanthrene dihydrodiolepoxides as well as 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine.

Pub. Date : 2006 Apr 15

PMID : 16137733






1 Functional Relationships(s)
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1 First, it was shown that HCEC cells express sulfotransferase 1A1, which is needed to metabolize N-OH-PhIP to the corresponding N-sulfonyloxy derivative, the direct precursor molecule of genotoxic nitrenium ions. nitrenium sulfotransferase family 1A member 1 Homo sapiens