Pub. Date : 2005 Dec
PMID : 16135656
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CYP2A6 AND CYP2B6 are involved in nornicotine formation from nicotine in humans: interindividual differences in these contributions. | Nicotine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 2 | The nicotine N-demethylase activity at 100 microM nicotine was significantly correlated with the CYP2B6 contents (r = 0.677, p < 0.05) and S-mephenytoin N-demethylase activities (r = 0.740, p < 0.005). | Nicotine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 3 | These results as well as the inhibition analyses suggested that CYP2A6 and CYP2B6 would significantly contribute to the nicotine N-demethylation at low and high substrate concentrations, respectively. | Nicotine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |