Pub. Date : 2005 Aug
PMID : 16125105
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Enzymatic metabolism of ergosterol by cytochrome p450scc to biologically active 17alpha,24-dihydroxyergosterol. | Ergosterol | cytochrome P450 family 11 subfamily A member 1 | Homo sapiens |
| 2 | We demonstrate the metabolism of ergosterol by cytochrome P450scc in either a reconstituted system or isolated adrenal mitochondria. | Ergosterol | cytochrome P450 family 11 subfamily A member 1 | Homo sapiens |
| 3 | Thus, in comparison with cholesterol and 7-dehydrocholesterol, the 24-methyl group and the C22-C23 double bond of ergosterol prevent side chain cleavage by P450scc and change the enzyme"s hydroxylase activity from C22 and C20, to C24 and C17, generating bioactive product. | Ergosterol | cytochrome P450 family 11 subfamily A member 1 | Homo sapiens |