Pub. Date : 2005 Sep
PMID : 16123402
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Perturbations of cGMP levels in isolated ROS suspensions by PDE inhibitors were quantitated by a cGMP enzyme-linked immunoassay. | Cyclic GMP | aldehyde dehydrogenase 7 family member A1 | Homo sapiens |
| 2 | In intact ROS, PDE inhibitors elevated cGMP levels, but none fully inhibited PDE6. | Cyclic GMP | aldehyde dehydrogenase 7 family member A1 | Homo sapiens |
| 3 | In intact ROS, high PDE6 concentrations, binding of the gamma-subunit to the active site, and calcium feedback mechanisms attenuate the effectiveness of PDE inhibitors to inhibit PDE6 and disrupt the cGMP signaling pathway during visual transduction. | Cyclic GMP | aldehyde dehydrogenase 7 family member A1 | Homo sapiens |