Pub. Date : 2005 Sep
PMID : 16108051
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice. | Fatty Acids | adiponectin, C1Q and collagen domain containing | Mus musculus |
| 2 | Circulating adiponectin levels were significantly elevated by chronic ethanol administration to mice consuming a diet high in saturated fat. | Fatty Acids | adiponectin, C1Q and collagen domain containing | Mus musculus |
| 3 | The increase in circulating adiponectin was associated with the activation a set of hepatic signaling pathways mediated through AMP-activated protein kinase, PPAR-alpha, and PPAR-gamma coactivator alpha, which in turn led to markedly increased rates of fatty acid oxidation, prevention of hepatic steatosis, and alleviation of liver enzyme changes. | Fatty Acids | adiponectin, C1Q and collagen domain containing | Mus musculus |
| 4 | Furthermore, treatment of rat 3T3-L1 adipocytes with saturated fatty acids (palmitic or stearic acids) in the presence of ethanol increased secretion of adiponectin and enhanced activity of a mouse adiponectin promoter. | Fatty Acids | adiponectin, C1Q and collagen domain containing | Mus musculus |
| 5 | In conclusion, the protective action of saturated fat against the development of alcoholic fatty liver in mice is partially mediated through induction of adiponectin. | Fatty Acids | adiponectin, C1Q and collagen domain containing | Mus musculus |