Title : Defunctionalized lobeline analogues: structure-activity of novel ligands for the vesicular monoamine transporter.

Pub. Date : 2005 Aug 25

PMID : 16107155






2 Functional Relationships(s)
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1 (-)-Lobeline (2R,6S,10S), an antagonist at nicotinic acetylcholine receptors (nAChRs), inhibits the neurochemical and behavioral effects of methamphetamine and inhibits dopamine transporter (DAT) and vesicular monoamine transporter (VMAT2) function. Lobeline solute carrier family 18 member A2 Homo sapiens
2 Generally, all of these analogues had lower affinities at alpha4beta2 and alpha7 nAChRs compared to lobeline, thereby increasing selectivity for VMAT2. Lobeline solute carrier family 18 member A2 Homo sapiens