Pub. Date : 2005 Aug 15
PMID : 16103219
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Two enzymes, thymidine kinase 1 (TK1) and thymidylate kinase (TMPK), involved in dTTP formation are the targets of the APC/C pathway. | thymidine 5'-triphosphate | deoxythymidylate kinase | Homo sapiens |
| 2 | Two enzymes, thymidine kinase 1 (TK1) and thymidylate kinase (TMPK), involved in dTTP formation are the targets of the APC/C pathway. | thymidine 5'-triphosphate | deoxythymidylate kinase | Homo sapiens |
| 3 | Overexpression of wild-type TK1 and TMPK induces a four- to fivefold increase in the cellular dTTP pool without promoting spontaneous mutations in the hprt (hypoxanthine-guanine phosphoribosyl transferase) gene. | thymidine 5'-triphosphate | deoxythymidylate kinase | Homo sapiens |
| 4 | In contrast, coexpression of nondegradable TK1 and TMPK expands the dTTP pool size 10-fold accompanied by a drastic dNTP pool imbalance. | thymidine 5'-triphosphate | deoxythymidylate kinase | Homo sapiens |