Title : Effects of pO2 on the activation of skeletal muscle ryanodine receptors by NO: a cautionary note.

Pub. Date : 2005 Nov

PMID : 16099502






2 Functional Relationships(s)
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1 A role for O2 was based on the observation that RyR1 can be activated by submicromolar NO at physiological ( approximately 10 mmHg) but not ambient (approximately 150 mmHg) pO2. PO-2 ryanodine receptor 1 Homo sapiens
2 At ambient pO2, these critical thiols were oxidized but incubation at low pO2 reset the redox state of these thiols, closed RyR1 channels and made these thiols available for nitrosation by low NO concentrations. PO-2 ryanodine receptor 1 Homo sapiens