Title : Amentoflavone and its derivatives as novel natural inhibitors of human Cathepsin B.

Pub. Date : 2005 Oct 15

PMID : 16084098






1 Functional Relationships(s)
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1 Herein, we report the structure-activity relationship (SAR) and binding mechanism of three biflavones, amentoflavone (AMF1), 4"""-methylamentoflavone (AMF2) and 7"",4"""-dimethylamentoflavone (AMF3), isolated from Taxodium mucronatum by us as novel natural inhibitors of human CatB with strong inhibitory activities at IC50 values of 1.75, 1.68 and 0.55muM, respectively. amentoflavone G protein pathway suppressor 2 Homo sapiens