Pub. Date : 2005 Jun 15
PMID : 16083584
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | [Adenovirus mediated antisense c-myc gene on the chemotherapy sensitivity of osteosarcoma cells to cisplatin]. | Cisplatin | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 2 | OBJECTIVE: To construct the recombinant adenovirus encoding antisense c-myc fragment and to investigate its effect on the chemotherapy sensitivity of osteosarcoma MG-63 cells to cisplatin. | Cisplatin | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 3 | Ad-Asc-myc down-regulated the expression of c-myc protein after transfected MG-63 cells for 48 h, combined with the treatment of 2.0, 5.0 microg/ml cisplatin for 2 h could inhibit tumor cells proliferation in vitro by 33.4% and 54.2% respectively, which were significantly difference compared with control recombinant adenovirus (Ad-LacZ) groups (P < 0.05). | Cisplatin | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 4 | Ad-Asc-myc down-regulated the expression of c-myc protein after transfected MG-63 cells for 48 h, combined with the treatment of 2.0, 5.0 microg/ml cisplatin for 2 h could inhibit tumor cells proliferation in vitro by 33.4% and 54.2% respectively, which were significantly difference compared with control recombinant adenovirus (Ad-LacZ) groups (P < 0.05). | Cisplatin | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 5 | Acridine Orange staining and FCM analysis showed that Ad-Asc-myc could induce apoptosis of transfected cells, which was enhanced by the treatment of cisplatin cell. | Cisplatin | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 6 | CONCLUSION: Ad-Asc-myc increases the chemotherapy sensitivity of osteosarcoma MG-63 cells to cisplatin as well as induced apoptosis. | Cisplatin | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |