Title : Crystal packing mediates enantioselective ligand recognition at the peripheral site of acetylcholinesterase.

Pub. Date : 2005 Aug 10

PMID : 16076210






2 Functional Relationships(s)
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1 Recently, alkylene-linked heterodimers of tacrine (1) and 5-amino-5,6,7,8-tetrahydroquinolinone (2, hupyridone) were shown to exhibit higher acetylcholinesterase (AChE) inhibition than either monomeric 1 or 2. 5-amino-5,6,7,8-tetrahydroquinolin-2(1H)-one acetylcholinesterase (Cartwright blood group) Homo sapiens
2 Recently, alkylene-linked heterodimers of tacrine (1) and 5-amino-5,6,7,8-tetrahydroquinolinone (2, hupyridone) were shown to exhibit higher acetylcholinesterase (AChE) inhibition than either monomeric 1 or 2. 5-amino-5,6,7,8-tetrahydroquinolin-2(1H)-one acetylcholinesterase (Cartwright blood group) Homo sapiens