Title : The polypeptide part of human chorionic gonadotrophin affects the kinetics of alpha 6-sialylation of its N-linked glycans but does not alter the branch specificity of CMP-NeuAc:Gal beta 1----4GlcNAc-R alpha 2----6-sialyltransferase.

Pub. Date : 1992 Apr

PMID : 1606356






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Initial rates of sialic acid incorporation into the desialylated glycans of hCG alpha and hCG beta in the heterodimer were higher with the alpha-subunit. N-Acetylneuraminic Acid chorionic gonadotropin subunit beta 5 Homo sapiens
2 1H-NMR spectroscopy (400 MHz) of the glycan chains, alpha 6-sialylated in vitro, showed that the enzyme highly prefers the galactosyl residue at the Gal beta 1----4GlcNAc beta 1----2-Man alpha 1----3Man branch for attachment of the first mol of sialic acid into the diantennary glycans of desialylated hCG. N-Acetylneuraminic Acid chorionic gonadotropin subunit beta 5 Homo sapiens