Title : A phase II trial with pharmacodynamic endpoints of the proteasome inhibitor bortezomib in patients with metastatic colorectal cancer.

Pub. Date : 2005 Aug 1

PMID : 16061869






1 Functional Relationships(s)
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1 There was a significant increase in the expression of HIF-1alpha relative to its transcriptional target CAIX following bortezomib, and a similar effect was also observed in a companion study using a human tumor xenograft model. Bortezomib carbonic anhydrase 9 Homo sapiens