Title : Directed evolution of protein switches and their application to the creation of ligand-binding proteins.

Pub. Date : 2005 Aug 9

PMID : 16061816






2 Functional Relationships(s)
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1 We demonstrate this approach by recombining the genes coding for TEM1 beta-lactamase (BLA) and the Escherichia coli maltose binding protein (MBP) to create a family of MBP-BLA hybrids in which maltose is a positive or negative effector of beta-lactam hydrolysis. beta-Lactams beta-lactamase Escherichia coli
2 We demonstrate this approach by recombining the genes coding for TEM1 beta-lactamase (BLA) and the Escherichia coli maltose binding protein (MBP) to create a family of MBP-BLA hybrids in which maltose is a positive or negative effector of beta-lactam hydrolysis. beta-Lactams beta-lactamase Escherichia coli