Title : Securin and separase phosphorylation act redundantly to maintain sister chromatid cohesion in mammalian cells.

Pub. Date : 2005 Oct

PMID : 16030258






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Securin(-/-)separase(+/S1121A) cells are viable but fail to maintain sister chromatid cohesion in response to the disruption of spindle microtubules, show enhanced sensitivity to nocodazole, and cannot recover from prometaphase arrest. Nocodazole PTTG1 regulator of sister chromatid separation, securin Homo sapiens