Pub. Date : 2005 Jul
PMID : 16012949
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Glibenclamide stimulates fluid secretion in rodent cholangiocytes through a cystic fibrosis transmembrane conductance regulator-independent mechanism. | Glyburide | cystic fibrosis transmembrane conductance regulator | Mus musculus |
| 2 | Glibenclamide, a sulfonylurea and a known CFTR inhibitor, paradoxically stimulates cholangiocyte secretion. | Glyburide | cystic fibrosis transmembrane conductance regulator | Mus musculus |
| 3 | Glibenclamide, unlike secretin and forskolin, was able to stimulate secretion in Cftr tm1Unc mice, thus indicating that this secretory mechanism was preserved. | Glyburide | cystic fibrosis transmembrane conductance regulator | Mus musculus |
| 4 | CONCLUSIONS: The ability of glibenclamide to stimulate secretion in CFTR-defective mice makes sulfonylureas a model class of compounds to design drugs useful in the treatment of cystic fibrosis with liver impairment and possibly of other cholestatic diseases. | Glyburide | cystic fibrosis transmembrane conductance regulator | Mus musculus |