Title : Sortilin is essential and sufficient for the formation of Glut4 storage vesicles in 3T3-L1 adipocytes.

Pub. Date : 2005 Jul

PMID : 15992544






2 Functional Relationships(s)
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1 Here, we report that GSVs are formed in differentiating 3T3-L1 adipocytes upon induction of sortilin on day 2 of differentiation. gsvs sortilin 1 Homo sapiens
2 Forced expression of Glut4 prior to induction of sortilin leads to rapid degradation of the transporter, whereas overexpression of sortilin increases formation of GSVs and stimulates insulin-regulated glucose uptake. gsvs sortilin 1 Homo sapiens