Pub. Date : 2005 Oct
PMID : 15987777
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Oxidation of tamoxifen by human flavin-containing monooxygenase (FMO) 1 and FMO3 to tamoxifen-N-oxide and its novel reduction back to tamoxifen by human cytochromes P450 and hemoglobin. | Tamoxifen | flavin containing dimethylaniline monoxygenase 3 | Homo sapiens |
| 2 | Oxidation of tamoxifen by human flavin-containing monooxygenase (FMO) 1 and FMO3 to tamoxifen-N-oxide and its novel reduction back to tamoxifen by human cytochromes P450 and hemoglobin. | Tamoxifen | flavin containing dimethylaniline monoxygenase 3 | Homo sapiens |
| 3 | The current study demonstrates that human FMO1 and FMO3 catalyze TAM N-oxidation to TNO and that cytochromes P450 (P450s), but not FMOs, reduce TNO to TAM. | Tamoxifen | flavin containing dimethylaniline monoxygenase 3 | Homo sapiens |