Title : Local anesthetic interaction with human ether-a-go-go-related gene (HERG) channels: role of aromatic amino acids Y652 and F656.

Pub. Date : 2005 Jul

PMID : 15983462






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The aim of this study was to determine the effect of the mutations Y652A and F656A in the putative drug binding region of HERG on the inhibition by bupivacaine, ropivacaine, and mepivacaine. Bupivacaine potassium voltage-gated channel subfamily H member 2 Homo sapiens
2 METHODS: The authors examined the inhibition of wild-type and mutant HERG channels, transiently expressed in Chinese hamster ovary cells by bupivacaine, ropivacaine, and mepivacaine. Bupivacaine potassium voltage-gated channel subfamily H member 2 Homo sapiens