Pub. Date : 2005 Sep 2
PMID : 15983031
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We demonstrate the role of p53-mediated caspase-2 activation in the mitochondrial release of apoptosis-inducing factor (AIF) in cisplatin-treated renal tubular epithelial cells. | Cisplatin | caspase 2 | Homo sapiens |
| 2 | Caspase-2 and -3 that were predominantly activated in response to cisplatin provided a unique model to study the role of these caspases in AIF release. | Cisplatin | caspase 2 | Homo sapiens |
| 3 | Caspase-2 and -3 that were predominantly activated in response to cisplatin provided a unique model to study the role of these caspases in AIF release. | Cisplatin | caspase 2 | Homo sapiens |
| 4 | Cisplatin-treated caspase-3 (+/+) and caspase-3 (-/-) cells exhibited similar AIF translocation to the nuclei, suggesting that caspase-3 does not affect AIF translocation, and thus, caspase-2 may be involved in the translocation. | Cisplatin | caspase 2 | Homo sapiens |
| 5 | Caspase-2 activation was a critical response from p53, which was markedly induced and phosphorylated in cisplatin-treated cells. | Cisplatin | caspase 2 | Homo sapiens |
| 6 | The p53 inhibitor pifithrin-alpha or p53 siRNA prevented both cisplatin-induced caspase-2 activation and mitochondrial release of AIF. | Cisplatin | caspase 2 | Homo sapiens |
| 7 | Caspase-2 activation was dependent on the p53-responsive gene, PIDD, a death domain-containing protein that was induced by cisplatin in a p53-dependent manner. | Cisplatin | caspase 2 | Homo sapiens |
| 8 | These results suggest that caspase-2 activation mediated by p53 is an important pathway involved in the mitochondrial release of AIF in response to cisplatin injury. | Cisplatin | caspase 2 | Homo sapiens |