Title : Comparison of human and monkey peptide transporters: PEPT1 and PEPT2.

Pub. Date : 2004 May-Jun

PMID : 15981923






2 Functional Relationships(s)
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1 In this study, it was first verified that monkey intestine transports a model dipeptide, Gly-Sar, in a proton-dependent manner (0.30 +/- 0.05 pmol cm(-2) s(-1) at pH 6.0 and 0.10 +/- 0.03 pmol cm(-2) s(-1) at pH 7.4) in the absorptive direction, presumably by monkey PEPT1. Glycine solute carrier family 15 member 1 Homo sapiens
2 Functional comparison of human and monkey peptide transporters expressed in HeLa cells suggested that functionalities of PEPT1 and PEPT2 were largely conserved in terms of Gly-Sar uptake kinetics and inhibitor specificity (for most tested substrates). Glycine solute carrier family 15 member 1 Homo sapiens