Title : Induction of competing apoptotic and survival signaling pathways in the macrophage by the ribotoxic trichothecene deoxynivalenol.

Pub. Date : 2005 Sep

PMID : 15976193






2 Functional Relationships(s)
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1 DON exposure evoked BAX translocation to mitochondria and corresponding cytochrome C release but did not alter mitochondrial membrane potential. deoxynivalenol BCL2 associated X, apoptosis regulator Homo sapiens
2 Taken together, the results indicate that DON initiates competing apoptotic (p38/p53/Bax/Mitochondria/Caspase-3) and survival (ERK/AKT/p90Rsk/Bad) pathways in the macrophage. deoxynivalenol BCL2 associated X, apoptosis regulator Homo sapiens