Title : Imaging multidrug resistance P-glycoprotein transport function using microPET with technetium-94m-sestamibi.

Pub. Date : 2005 Jan-Mar

PMID : 15967124






2 Functional Relationships(s)
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1 The positron-emitting radiotracer hexakis(2-methoxyisobutylisonitrile)-(94m)Tc ((94m)Tc-MIBI) was synthesized and validated in cell transport studies as a substrate for MDR1 Pgp. Technetium Tc 99m Sestamibi phosphoglycolate phosphatase Mus musculus
2 In vivo small-scale PET imaging and biodistribution studies of mdr1a/1b (-/-) gene deleted and wild-type mice demonstrated the use of (94m)Tc-MIBI to detect Pgp function. Technetium Tc 99m Sestamibi phosphoglycolate phosphatase Mus musculus