Title : Anthocyanidins inhibit cyclooxygenase-2 expression in LPS-evoked macrophages: structure-activity relationship and molecular mechanisms involved.

Pub. Date : 2005 Aug 1

PMID : 15963474






2 Functional Relationships(s)
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1 Western blotting analysis indicated that delphinidin inhibited the degradation of IkappaB-alpha, nuclear translocation of p65 and CCAAT/enhancer-binding protein (C/EBP)delta and phosphorylation of c-Jun, but not CRE-binding protein (CREB). delphinidin CCAAT/enhancer binding protein (C/EBP), delta Mus musculus
2 Thus, our results demonstrated that LPS-induced COX-2 expression by activating MAPK pathways and delphinidin suppressed COX-2 by blocking MAPK-mediated pathways with the attendant activation of nuclear factor-kappaB (NF-kappaB), activator protein-1 (AP-1) and C/EBPdelta. delphinidin CCAAT/enhancer binding protein (C/EBP), delta Mus musculus