Title : Synthesis and SAR/3D-QSAR studies on the COX-2 inhibitory activity of 1,5-diarylpyrazoles to validate the modified pharmacophore.

Pub. Date : 2005 Oct

PMID : 15961192






1 Functional Relationships(s)
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1 In general, the sulfonamide analogues with a CHF2 at C-3 were found to be more potent than those having a CF3 group. Sulfonamides hes related family bHLH transcription factor with YRPW motif 1 Homo sapiens