Title : Kappa opioid receptor activation disrupts prepulse inhibition of the acoustic startle in rats.

Pub. Date : 2005 Jun 15

PMID : 15953492






1 Functional Relationships(s)
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1 RESULTS: U50488 (1.25, 2.5, and 5 mg/kg, subcutaneous [SC]) induced a dose-dependent reduction of PPI, which was efficiently prevented by the selective KOR antagonist norbinaltorphimine (nor-BNI, 10 mg/kg, SC), as well as by the atypical antipsychotic clozapine (5, 8 mg/kg, intraperitoneal [IP]) but not by the typical antipsychotic haloperidol (.1, .5 mg/kg, IP). norbinaltorphimine opioid receptor kappa 1 Homo sapiens