Pub. Date : 2005
PMID : 15952884
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Recent biochemical and structural data make it possible to understand at least in outline the structural basis for tRNA selection, in which codon recognition by cognate tRNA results in the hydrolysis of GTP by EF-Tu over 75 A away. | Guanosine Triphosphate | Tu translation elongation factor, mitochondrial | Homo sapiens |
| 2 | Part of the additional binding energy of cognate tRNA is used to induce conformational changes in the ribosome that stabilize a transition state for GTP hydrolysis by EF-Tu and subsequently result in accelerated accommodation of tRNA into the peptidyl transferase center. | Guanosine Triphosphate | Tu translation elongation factor, mitochondrial | Homo sapiens |
| 3 | However, many fundamental questions remain, such as the mechanism of activation of GTP hydrolysis by EF-Tu, and the relationship between decoding and frameshifting. | Guanosine Triphosphate | Tu translation elongation factor, mitochondrial | Homo sapiens |