Title : Correlations between antitumor activities of fluoropyrimidines and DPD activity in lung tumor xenografts.

Pub. Date : 2005 Jul

PMID : 15944764






2 Functional Relationships(s)
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1 The purposes of this study were to evaluate the antitumor activity of S-1 (1 M tegafur, 0.4 M 5-chloro-2,4-dihydroxypyridine and 1 M potassium oxonate) on human lung tumor xenografts, as compared with other fluoro-pyrimidines, and to investigate the relationships between fluoropyrimidine antitumor activities and four distinct enzymatic activities involved in the phosphorylation and degradation pathways of 5-fluorouracil (5-FU) metabolism. Tegafur proteasome 26S subunit, non-ATPase 1 Homo sapiens
2 Cluster analysis, on the basis of antitumor activity, indicated that S-1/UFT and 5"-DFUR/capecitabine/5-FU could be classified into another group. Tegafur proteasome 26S subunit, non-ATPase 1 Homo sapiens